Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.

Journal of clinical periodontology - 1 Apr 2008

Takeuchi-Hatanaka Kazu, Ohyama Hideki, Nishimura Fusanori, Kato-Kogoe Nahoko, Soga Yoshihiko, Matsushita Sho, Nakasho Keiji, Yamanegi Koji, Yamada Naoko, Terada Nobuyuki, Takashiba Shogo

Abstract excerpt

OBJECTIVES: The expression of interleukin (IL)-12Rbeta2 molecule is a crucial regulatory factor in the T-helper type (Th) 1 differentiation of T cells. To elucidate the role of the cell-mediated immune (CMI) response in the pathogenesis of periodontitis, Japanese periodontal patients were subjected to single nucleotide polymorphism (SNP) analyses of the 5' flanking region of IL12RB2, whose variants are frequently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Alveolar Bone Loss

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibodies, Bacterial

Share to Gram-Negative Bacterial Infections

Share to Immunity, Cellular

Share to Periodontitis

Share to Statistics, Nonparametric

Source

Identifiers

PMID: 18353079
DOI: 10.1111/j.1600-051X.2008.01208.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.PMID 18353079Read ↗

Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity.Semantic proximity Read ↗

Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene.Semantic proximity Read ↗

The Association between IL2 Genotypes and Risk and Severity of Chronic Periodontitis in a Chinese Han Population: A Case-control Study.Semantic proximity Read ↗

FcgammaRIIB gene polymorphisms in Japanese periodontitis patients.Semantic proximity Read ↗

Polymorphisms assessment in the promoter region of IL12RB2 in Amazon leprosy patients.Semantic proximity Read ↗

Association of the IL-1RN2 allele with periodontal diseases.Semantic proximity Read ↗

Association of variants in the IL12B gene with leprosy and tuberculosis.Semantic proximity Read ↗

Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.Semantic proximity Read ↗

Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients.Semantic proximity Read ↗

Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population.Semantic proximity Read ↗

Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese.Semantic proximity Read ↗

Association of interleukin 12A gene polymorphisms with oral lichen planus in Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.