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Article

Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Sept 2008

Ohyama Hideki, Kato-Kogoe Nahoko, Nishimura Fusanori, Takeuchi-Hatanaka Kazu, Matsushita Sho, Yamanegi Koji, Yamada Naoko, Hata Masaki, Nakasho Keiji, Terada Nobuyuki

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the 5' flanking region of IL12RB2 are frequently detected in lepromatous leprosy patients, and may be possible immunogenetic factors that reduce transcriptional activity of the IL-12Rbeta2 gene in Jurkat T cells. This study determined the functional effects of these SNPs on NK-cell activity, including IFN-gamma production and IL-12Rbeta2 gene expression. Reporter gene...

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Identifiers

PMID: 18771340
DOI: 10.1089/jir.2008.0133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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