Article
Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator.
Genes and immunity - 1 Mar 2019
Reeme Allison E, Claeys Tiffany A, Aggarwal Praful, Turner Amy J, Routes John M, Broeckel Ulrich, Robinson Richard T
Abstract excerpt
Human IL12RB1 is an autosomal gene that is essential for mycobacterial disease resistance and T cell differentiation. Using primary human tissue and PBMCs, we demonstrate that lung and T cell IL12RB1 expression is allele-biased, and the extent to which cells express one IL12RB1 allele is unaffected by activation. Furthermore following its expression the IL12RB1 pre-mRNA is processed into either IL12RB1 Isoform 1...
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