Article
A functional variant in IL12B promoter modulates its expression and associates with increased risk of allergic asthma.
Genes and immunity - 1 Jun 2013
Xu Z, Pei L, Zhang F, Hu X, Gui Y, Wang L, Wu B
Abstract excerpt
The interleukin-12B (IL12B) gene encodes the p40 chain of IL-12, a pro-inflammatory cytokine that antagonizes Th2 phenotype and, hence, may have a critical role in the pathogenesis of allergic asthma. In this report, we describe the identification of a novel IL12B promoter polymorphism (T-to-A exchange) at position -536. The IL12B -536AA genotype was significantly associated with asthma in the Chinese populations...
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