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Article

Differential expression and function of human IL-12Rβ2 polymorphic variants.

Molecular immunology - 1 Dec 2013

de Paus Roelof A, Geilenkirchen Marije A, van Riet Sander, van Dissel Jaap T, van de Vosse Esther

Abstract excerpt

The receptor for interleukin-12, formed by IL-12Rβ1 and IL-12Rβ2, mediates the type I immune responses of various types of lymphocytes. Polymorphisms in IL12RB2, the gene encoding IL-12Rβ2, were reported to be associated with several immune related diseases, such as Crohn's disease. Because the IL23R and IL12RB2 genes are located in close proximity on the genome, the reported associations might also be...

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PMID: 23911393
DOI: 10.1016/j.molimm.2013.07.002

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