Article
A novel polymorphic GATA site in the human IL-12Rbeta2 promoter region affects transcriptional activity.
Tissue antigens - 1 Jun 2004
van Rietschoten J G I, Westland R, van den Bogaard R, Nieste-Otter M A, van Veen A, Jonkers R E, van der Pouw Kraan T C T M, den Hartog M T, Wierenga E A
Abstract excerpt
Interleukin-12 (IL-12) is a potent inducer of interferon-gamma production by T cells and is a major factor for the development of T-helper 1 (Th1) cells. It exerts its biological effects through binding to the IL-12 receptor (IL-12R), a heterodimer composed of a 1 and a beta2 subunits. The signaling beta2 chain is expressed on Th1 cells and to a lesser extent on Th0 cells, but not on Th2 cells, rendering these...
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