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Article

Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2016

Motojima Masaru, Ogiwara Sanae, Matsusaka Taiji, Kim Sang Yong, Sagawa Nobuho, Abe Koichiro, Ohtsuka Masato

Abstract excerpt

Foxc2 is a single-exon gene and a key regulator in development of multiple organs, including kidney. To avoid embryonic lethality of conventional Foxc2 knockout mice, we conditionally deleted Foxc2 in kidneys. Conditional targeting of a single-exon gene involves the large floxed gene segment spanning from promoter region to coding region to avoid functional disruption of the gene by the insertion of a loxP site....

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PMID: 26542959
DOI: 10.1007/s00335-015-9610-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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