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Article

Molecular characterization of Cdh12-SCON conditional knockout mice reveals unexpected splicing changes.

Transgenic research - 2 May 2026

Ten Hoor Mayke A C, Linssen Margot M, Brouwers Conny M, Claassens Jill W C, Mulder Jaap, Hohenstein Peter

Abstract excerpt

Functional validation of candidate genes in congenital anomalies of the kidneys and urinary tract (CAKUT) and other disorders is essential for translating genetic discoveries into clinical applications. Conditional knockout mouse models are indispensable for studying gene function in complex organ systems. The Short Conditional intrON (SCON) system accelerates the generation of such models by inserting the...

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PMID: 42069999
DOI: 10.1007/s11248-026-00496-7
PMCID: PMC13135578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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