Article
Generation of conditional alleles for Foxc1 and Foxc2 in mice.
Genesis (New York, N.Y. : 2000) - 1 Oct 2012
Sasman Amy, Nassano-Miller Carey, Shim Kyoo Seok, Koo Hyun Young, Liu Ting, Schultz Kathryn M, Millay Meredith, Nanano Atsushi, Kang Myengmo, Suzuki Takashi, Kume Tsutomu
Abstract excerpt
The Forkhead box transcription factors, Foxc1 and Foxc2, are crucial for development of the eye, cardiovascular network, and other physiological systems, but their cell-type specific and postdevelopmental functions are unknown, in part because conventional (i.e., whole-organism) homozygous-null mutations of either factor result in perinatal death. Here, we describe the generation of mice with conditional-null...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.