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Article

Production and Analysis of Conditional KO Mice of CCN2 in Kidney.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Toda Naohiro, Yokoi Hideki, Mori Kiyoshi, Mukoyama Masashi

Abstract excerpt

CCN2 has been shown to be closely involved in the progression of renal fibrosis, indicating the potential of CCN2 inhibition as a therapeutic target. Although the examination of the phenotypes of adult CCN2 knockout mice with renal diseases has yielded valuable scientific insights, perinatal death has limited studies of CCN2 in vivo. Conditional knockout technology has become widely used for the deletion of genes...

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Source

Identifiers

PMID: 27734390
DOI: 10.1007/978-1-4939-6430-7_31

Genes

CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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