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Article

Establishment of Nephrin Reporter Mice and Use for Chemical Screening

30 Jun 2016

Abstract excerpt

Nephrin is a critical component of glomerular filtration barrier, which is important to maintain glomerular structure and avoid proteinuria. Downregulation of nephrin expression is commonly observed at early stage of glomerular disorders, suggesting that methods to increase nephrin expression in podocytes may have therapeutic utility. Here, we generated a knockin mouse line carrying single copy of 5.5 kb nephrin...

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PMID: 27362433
DOI: 10.1371/journal.pone.0157497

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