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Article

Generation of Mice Harboring Bicc1 Conditional Null Alleles.

Genesis (New York, N.Y. : 2000) - 1 Feb 2026

Liu Chia-Feng, Leon Steven, Herrig Isabella, Wessely Oliver, Tang W H Wilson

Abstract excerpt

Bicaudal C1 (Bicc1) encodes an RNA-binding protein critical for many organ development and epithelial tissue homeostasis. Bicc1 null mutations have been shown to lead to the development of polycystic kidney disease (PKD) and death at an early prenatal stage. To elucidate the tissue-specific functions of Bicc1, we engineered two independent conditional knockout (cKO) mouse lines targeting distinct exonic regions...

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Identifiers

PMID: 41508907
DOI: 10.1002/dvg.70038
PMCID: PMC12784183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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