Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.

doi:10.18632/oncotarget.8176

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.

Oncotarget - 19 Apr 2016

Chang Xiao-Long, Tan Lin, Tan Meng-Shan, Wang Hui-Fu, Tan Chen-Chen, Zhang Wei, Zheng Zhan-Jie, Kong Ling-Li, Wang Zi-Xuan, Jiang Teng, Yu Jin-Tai, Tan Lan

Abstract excerpt

The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as a potential genetic modifier for Alzheimer's disease (AD). Previous reports identified that HMGCR rs3846662 polymorphism is associated with biosynthesis of cholesterol in AD pathology. In order to assess the involvement of the HMGCR polymorphism in the risk of late-onset AD (LOAD) in northern Han Chinese, we performed a case-control study of 2334...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Alzheimer Disease

Share to Asian People

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Hydroxymethylglutaryl CoA Reductases

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 27009838
DOI: 10.18632/oncotarget.8176
PMCID: PMC5008397

Genes

HMGCR
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.PMID 27009838Read ↗

Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Semantic proximity Read ↗

Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese.Semantic proximity Read ↗

HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study.Semantic proximity Read ↗

Validate association of gene loci and establish genetic risk prediction models for late-onset Alzheimer's disease in Chinese populations.Semantic proximity Read ↗

Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.Semantic proximity Read ↗

Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.Semantic proximity Read ↗

Replication of the MTHFD1L gene association with late-onset Alzheimer's disease in a Northern Han Chinese population.Semantic proximity Read ↗

Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis.Semantic proximity Read ↗

Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.Semantic proximity Read ↗

Association between LRP1 C766T polymorphism and Alzheimer's disease susceptibility: a meta-analysis.Semantic proximity Read ↗

ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.Semantic proximity Read ↗

FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.