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Article

Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk.

Brain research - 14 Jul 2009

Rodríguez-Rodríguez Eloy, Mateo Ignacio, Infante Jon, Llorca Javier, García-Gorostiaga Inés, Vázquez-Higuera José Luis, Sánchez-Juan Pascual, Berciano José, Combarros Onofre

Abstract excerpt

A number of studies suggest that increased cellular cholesterol levels induce high amyloid beta (Abeta) production, which is central to the pathogenesis of Alzheimer's disease (AD). In the brain, glial cells have hydroxy-methylglutaryl-coenzyme A reductase (HMGCR) as the major rate-limiting enzym...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19446537
DOI: 10.1016/j.brainres.2009.05.019

Genes

ABCA1
HMGCR
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19446537-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk.PMID 19446537Read ↗

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