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Article

Genetic Polymorphisms in the HMGCR Gene and Associations with Cognitive Decline in Parkinson's Disease Patients.

International journal of molecular sciences - 17 Aug 2024

Pierzchlińska Anna, Sławek Jarosław, Kwaśniak-Butowska Magdalena, Malinowski Damian, Komaniecka Nina, Mak Monika, Czerkawska Anna, Kukowka Arnold, Białecka Monika

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor and non-motor symptoms including cognitive impairment and dementia. The etiopathogenesis of PD, as well as its protective and susceptibility factors, are still elusive. 3-Hydroxy-3-methyglutaryl coenzyme A reductase (HMGCR) is an enzyme regulating cholesterol synthesis. Single-nucleotide polymorphisms (SNPs) in the gene coding...

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PMID: 39201649
DOI: 10.3390/ijms25168964
PMCID: PMC11354436

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