Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.

doi:10.1097/FPC.0000000000000178

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Article

Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.

Pharmacogenetics and genomics - 1 Jan 2016

Leduc Valerie, Bourque Lucienne, Poirier Judes, Dufour Robert

Abstract excerpt

OBJECTIVES: To assess the contribution of the rs3846662 polymorphism of HMGCR on serum lipid levels and statin efficacy, we measured in vivo HMGCR mRNA and lipid levels in French Canadian individuals affected by heterozygous familial hypercholesterolemia due to the deletion of more than 15 kb of the LDLR gene. RESULTS: Men and women carrying the AA genotype at rs3846662, and no APOE4 allele, had higher levels of...

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Identifiers

PMID: 26466344
DOI: 10.1097/FPC.0000000000000178
PMCID: PMC5138058

Genes

HMGCR
LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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