Article
The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology.
Nature communications - 22 Mar 2024
Wang Xia, Wang Jiayu, Chen Yashuang, Qian Xiaojing, Luo Shiqi, Wang Xue, Ma Chao, Ge Wei
Abstract excerpt
In the ALDH2 rs671 variant, a guanine changes to an adenine, resulting in a dramatic decrease in the catalytic activity of the enzyme. Population-based data are contradictory about whether this variant increases the risk of Alzheimer's disease. In East Asian populations, the prevalence of the ALDH2 rs671 variant is 30-50%, making the National Human Brain Bank for Development and Function (the largest brain bank...
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