Article
ABCB1 gene variants, digoxin and risk of sudden cardiac death in a general population.
Heart (British Cardiac Society) - 1 Dec 2015
Niemeijer Maartje N, van den Berg Marten E, Deckers Jaap W, Aarnoudse Adrianus L H J, Hofman Albert, Franco Oscar H, Uitterlinden André G, Rijnbeek Peter R, Eijgelsheim Mark, Stricker Bruno H
Abstract excerpt
OBJECTIVE: The ATP-binding cassette B1 (ABCB1) gene encodes P-glycoprotein, a transport protein, which plays an important role in the bioavailability of digoxin. We aimed to investigate the interaction between variants within the ABCB1 gene and digoxin on the risk of sudden cardiac death (SCD). METHODS: Within the Rotterdam Study, a population-based cohort study in persons 45 years of age and older, we used Cox...
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