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Article

Influence of transporter polymorphisms on digoxin serum concentrations: a systematic review and meta-analysis.

Pharmacogenomics - 1 Jan 2026

Low Xin Yee, Badrul Hisham Muhammad Danish, Lee Jia Wen, Teh Lk

Abstract excerpt

INTRODUCTION: Polymorphisms in transporter (P-gp, OATP) genes affect digoxin pharmacokinetics and are crucial for predicting toxicity due to its narrow therapeutic index. However, evidence regarding their effects on digoxin serum concentrations remain inconsistent. This systematic review and meta-analysis aimed to evaluate the influence of transporter polymorphisms on digoxin serum concentrations. METHODS: A...

Topics

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ATP Binding Cassette Transporter, Subfamily B
Digoxin
ABCB1 gene
Polymorphism, Genetic
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

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Identifiers

PMID: 41811250
DOI: 10.1080/14622416.2026.2641750
PMCID: PMC13078199

Genes

ABCB1
SLCO1B1
SLCO1B3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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