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Article

The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patients.

European journal of clinical pharmacology - 1 Apr 2008

Dragonas Charalampos, Wagner Jan T, Heppner Hans J, Bertsch Thomas, Muhlberg Wolfgang, Wicklein Susanne, Pahl Andreas, Diewald Christine, Bachmakov Iouri, Sieber Cornel C, Fromm Martin F

Abstract excerpt

OBJECTIVE: Digitoxin is a known substrate of the efflux pump P-glycoprotein (gene name: ABCB1). P-glycoprotein expression was shown to be modulated by single nucleotide polymorphisms in the ABCB1 gene, but it remains unclear whether these polymorphisms influence digitoxin blood levels. Our objective was to examine the association of ABCB1 C3435T genotype and elevated serum digitoxin concentrations (SDC) in a...

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Share to ATP Binding Cassette Transporter, Subfamily B

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Source

Identifiers

PMID: 18080812
DOI: 10.1007/s00228-007-0418-x

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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