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Article

Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters.

European journal of clinical pharmacology - 1 May 2007

Comets Emmanuelle, Verstuyft Céline, Lavielle Marc, Jaillon Patrice, Becquemont Laurent, Mentré France

Abstract excerpt

OBJECTIVES: Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the multi-drug-resistance 1 (MDR1) gene coding for P-glycoprotein. METHODS: Thirty-two healthy...

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Identifiers

PMID: 17404720
DOI: 10.1007/s00228-007-0269-5
PMCID: PMC1963422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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