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Article

Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.

Scientific reports - 27 Jul 2020

Hsin Chih-Hsuan, Stoffel Marc S, Gazzaz Malaz, Schaeffeler Elke, Schwab Matthias, Fuhr Uwe, Taubert Max

Abstract excerpt

Effects of different genotypes on the pharmacokinetics of probe substrates may support their use as phenotyping agents for the activity of the respective enzyme or transporter. Digoxin is recommended as a probe substrate to assess the activity of the transporter P-glycoprotein (P-gp) in humans. Current studies on the individual effects of three commonly investigated single nucleotide polymorphisms (SNPs) of the...

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Identifiers

PMID: 32719417
DOI: 10.1038/s41598-020-69326-y
PMCID: PMC7385621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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