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Article

ABCB1 and SLCO1B3 Gene Polymorphisms and Their Impact on Digoxin Pharmacokinetics in Atrial Fibrillation Patients among the Tunisian Population.

Pharmacology - 1 Jan 2017

Tounsi Nejia, Trabelsi Imen, Kerkeni Emna, Grissa Mohamed Habib, Fredj Nizar, Sekma Adel, Mzali Malek, Hellara Ilhem, Monastiri Kamel, Douki Wahiba, Nouira Semir

Abstract excerpt

BACKGROUND: Digoxin is a substrate of P-glycoprotein (P-gp) and organic anion transporting polypeptide transporters that are encoded by ABCB1 and SLCO1B3 genes. Genetic polymorphisms in both genes may explain inter-individual variability of serum digoxin concentration (SDC). This study evaluates the possible effect of the most common ABCB1 and SLCO1B3 polymorphisms on SDC after a single oral dose of digoxin in...

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Source

Identifiers

PMID: 28208135
DOI: 10.1159/000457906

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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