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Article

ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations.

Bioinformatics (Oxford, England) - 15 Feb 2016

Chimusa Emile R, Mbiyavanga Mamana, Mazandu Gaston K, Mulder Nicola J

Abstract excerpt

MOTIVATION: Despite numerous successful Genome-wide Association Studies (GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may miss disease genes with weak genetic effects or strong epistatic effects due to the single-marker testing approach commonly used. GWAS may thus generate false negative or inconclusive results, suggesting the need for novel methods to combine effects of...

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Identifiers

PMID: 26508762
DOI: 10.1093/bioinformatics/btv619
PMCID: PMC5939890

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