networkGWAS: a network-based approach to discover genetic associations.

doi:10.1093/bioinformatics/btad370

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networkGWAS: a network-based approach to discover genetic associations.

Bioinformatics (Oxford, England) - 1 Jun 2023

Muzio Giulia, O'Bray Leslie, Meng-Papaxanthos Laetitia, Klatt Juliane, Fischer Krista, Borgwardt Karsten

Abstract excerpt

MOTIVATION: While the search for associations between genetic markers and complex traits has led to the discovery of tens of thousands of trait-related genetic variants, the vast majority of these only explain a small fraction of the observed phenotypic variation. One possible strategy to overcome this while leveraging biological prior is to aggregate the effects of several genetic markers and to test entire...

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PMID: 37285313
DOI: 10.1093/bioinformatics/btad370
PMCID: PMC10281858

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