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Article

A method for estimating coherence of molecular mechanisms in major human disease and traits.

BMC bioinformatics - 21 Oct 2020

Dozmorov Mikhail G, Cresswell Kellen G, Bacanu Silviu-Alin, Craver Carl, Reimers Mark, Kendler Kenneth S

Abstract excerpt

BACKGROUND: Phenotypes such as height and intelligence, are thought to be a product of the collective effects of multiple phenotype-associated genes and interactions among their protein products. High/low degree of interactions is suggestive of coherent/random molecular mechanisms, respectively. Comparing the degree of interactions may help to better understand the coherence of phenotype-specific molecular...

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Identifiers

PMID: 33087046
DOI: 10.1186/s12859-020-03821-x
PMCID: PMC7579960

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