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Article

Robust relationship inference in genome-wide association studies.

Bioinformatics (Oxford, England) - 15 Nov 2010

Manichaikul Ani, Mychaleckyj Josyf C, Rich Stephen S, Daly Kathy, Sale Michèle, Chen Wei-Min

Abstract excerpt

MOTIVATION: Genome-wide association studies (GWASs) have been widely used to map loci contributing to variation in complex traits and risk of diseases in humans. Accurate specification of familial relationships is crucial for family-based GWAS, as well as in population-based GWAS with unknown (or unrecognized) family structure. The family structure in a GWAS should be routinely investigated using the SNP data...

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Identifiers

PMID: 20926424
DOI: 10.1093/bioinformatics/btq559
PMCID: PMC3025716

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