NAT2 gene diversity and its evolutionary trajectory in the Americas.

doi:10.1038/tpj.2015.72

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Article

NAT2 gene diversity and its evolutionary trajectory in the Americas.

The pharmacogenomics journal - 1 Nov 2016

Bisso-Machado R, Ramallo V, Paixão-Côrtes V R, Acuña-Alonzo V, Demarchi D A, Sandoval J R S, Granara A A S, Salzano F M, Hünemeier T, Bortolini M C

Abstract excerpt

N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT2*4, the most frequent haplotypes are NAT2*5B...

Topics

Acetylation
Agriculture
American Indian or Alaska Native
Americas
Animals
Arylamine N-Acetyltransferase
Diet
Evolution, Molecular
Feeding Behavior
Gene Frequency
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Kinetics

Phenotype

Predatory Behavior

Xenobiotics

Source

Open in PubMed

Identifiers

PMID: 26503810
DOI: 10.1038/tpj.2015.72

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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