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Article

Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

BMC genetics - 27 Feb 2008

Sabbagh Audrey, Langaney André, Darlu Pierre, Gérard Nathalie, Krishnamoorthy Rajagopal, Poloni Estella S

Abstract excerpt

BACKGROUND: The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant data on other African populations. The Mandenka data were further included in a worldwide dataset...

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Source

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Identifiers

PMID: 18304320
DOI: 10.1186/1471-2156-9-21
PMCID: PMC2292740

Genes

NAT2
FST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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