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Article

A homogenizing process of selection has maintained an "ultra-slow" acetylation NAT2 variant in humans.

Human biology - 1 Jan 2014

Patillon B, Luisi P, Poloni E S, Boukouvala S, Darlu P, Genin E, Sabbagh A

Abstract excerpt

N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

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Source

Identifiers

PMID: 25836746
DOI: 10.13110/humanbiology.86.3.0185

Genes

NAT2
FST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A homogenizing process of selection has maintained an "ultra-slow" acetylation NAT2 variant in humans.PMID 25836746Read ↗

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