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Article

Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia.

European journal of human genetics : EJHG - 1 Feb 2008

Magalon Hélène, Patin Etienne, Austerlitz Frédéric, Hegay Tatyana, Aldashev Almaz, Quintana-Murci Lluís, Heyer Evelyne

Abstract excerpt

The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs. Variation at the NAT2 gene has been linked to the human acetylation capacity, either 'slow' or 'fast', which modifies susceptibility to cancer and adverse drug reactions. We investigated the possible influence of natural selection in shaping the acetylation phenotype and...

Read the complete abstract on PubMed

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Share to Acetylation
Share to Adaptation, Physiological

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Agriculture

Share to Arylamine N-Acetyltransferase

Share to Asia, Central

Share to Genetic Variation

Share to Genetics, Population

Share to Linkage Disequilibrium

Source

Identifiers

PMID: 18043717
DOI: 10.1038/sj.ejhg.5201963

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia.PMID 18043717Read ↗

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey.Semantic proximity Read ↗

A homogenizing process of selection has maintained an "ultra-slow" acetylation NAT2 variant in humans.Semantic proximity Read ↗

NAT2 gene diversity and its evolutionary trajectory in the Americas.Semantic proximity Read ↗

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.Semantic proximity Read ↗

Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene.Semantic proximity Read ↗

NAT2 sequence polymorphisms and acetylation profiles in Indians.Semantic proximity Read ↗

Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.Semantic proximity Read ↗

Arylamine N-acetyltransferase (NAT2) genotypes in a Turkish population.Semantic proximity Read ↗

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Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.Semantic proximity Read ↗

Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations.Semantic proximity Read ↗

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