Article
Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
American journal of human genetics - 1 Mar 2006
Patin Etienne, Barreiro Luis B, Sabeti Pardis C, Austerlitz Frédéric, Luca Francesca, Sajantila Antti, Behar Doron M, Semino Ornella, Sakuntabhai Anavaj, Guiso Nicole, Gicquel Brigitte, McElreavey Ken, Harding Rosalind M, Heyer Evelyne, Quintana-Murci Lluis
Abstract excerpt
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize various drugs and carcinogens. Functional variability at these genes has been associated with adverse drug reactions and cancer susceptibility. Mutations in NAT2 leading to the so-called slow-acetylation phenotype reach high frequencies worldwide, which questions the significance of altered acetylation in human...
Topics
- Acetylation
- Adaptation, Physiological
- Amino Acid Sequence
- Arylamine N-Acetyltransferase
- Evolution, Molecular
- Female
- Genes
- Genetic Variation
- Geography