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Article

Multiple advantageous amino acid variants in the NAT2 gene in human populations.

PloS one - 5 Sept 2008

Luca Francesca, Bubba Giuseppina, Basile Massimo, Brdicka Radim, Michalodimitrakis Emmanuel, Rickards Olga, Vershubsky Galina, Quintana-Murci Lluis, Kozlov Andrey I, Novelletto Andrea

Abstract excerpt

BACKGROUND: Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety of drugs of therapeutic use. Here, we explore the pattern of genetic variation in 12 human populations that significantly extend the geographic range and resolution of previous surveys, to test the hypothesis that different dietary regimens and lifestyles may explain inter-population...

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Source

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Identifiers

PMID: 18773084
DOI: 10.1371/journal.pone.0003136
PMCID: PMC2527519

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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