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Article

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey.

PloS one - 6 Apr 2011

Sabbagh Audrey, Darlu Pierre, Crouau-Roy Brigitte, Poloni Estella S

Abstract excerpt

Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a variety of xenobiotic compounds, including common therapeutic drugs and exogenous chemicals present in the diet and the environment. Many questions remain about the evolutionary mechanisms that have led to the high prevalence of slow acetylators in the human species. Evidence from recent surveys of NAT2 gene variation...

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Identifiers

PMID: 21494681
DOI: 10.1371/journal.pone.0018507
PMCID: PMC3071824

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey.PMID 21494681Read ↗

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A homogenizing process of selection has maintained an "ultra-slow" acetylation NAT2 variant in humans.Semantic proximity Read ↗

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

NAT2 gene diversity and its evolutionary trajectory in the Americas.Semantic proximity Read ↗

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.Semantic proximity Read ↗

Multiple advantageous amino acid variants in the NAT2 gene in human populations.Semantic proximity Read ↗

NAT2 sequence polymorphisms and acetylation profiles in Indians.Semantic proximity Read ↗

Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene.Semantic proximity Read ↗

Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.Semantic proximity Read ↗

Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.Semantic proximity Read ↗

Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene.Semantic proximity Read ↗

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