Article
Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.
The pharmacogenomics journal - 1 Apr 2007
Fuselli S, Gilman R H, Chanock S J, Bonatto S L, De Stefano G, Evans C A, Labuda D, Luiselli D, Salzano F M, Soto G, Vallejo G, Sajantila A, Pettener D, Tarazona-Santos E
Abstract excerpt
N-acetyltransferase 2 (NAT2), an important enzyme in clinical pharmacology, metabolizes antibiotics such as isoniazid and sulfamethoxazole, and catalyzes the transformation of aromatic and heterocyclic amines from the environment and diet into carcinogenic intermediates. Polymorphisms in NAT2 account for variability in the acetylator phenotype and the pharmacokinetics of metabolized drugs. Native Americans,...
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