Article
Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.
American journal of physiology. Gastrointestinal and liver physiology - 15 Dec 2015
Scheving Lawrence A, Zhang Xiuqi, Stevenson Mary C, Weintraub Michael A, Abbasi Annam, Clarke Andrea M, Threadgill David W, Russell William E
Abstract excerpt
Epidermal growth factor receptor (EGFR) and ERBB3 have been implicated in hepatocellular carcinogenesis (HCC). However, it is not known whether altering the activity of either EGFR or ERBB3 affects HCC development. We now show that Egfr(Dsk5) mutant mice, which have a gain-of-function allele that increases basal EGFR kinase activity, develop spontaneous HCC by 10 mo of age. Their tumors show increased activation...
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