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Liver regeneration and hepatocarcinogenesis in transforming growth factor-α-targeted mice

1 Mar 1996

Abstract excerpt

Transforming growth factor-alpha (TGF alpha), a member of the epidermal growth factor receptor ligand family, has been implicated in the regeneration and transformation of liver. Our recent development of mice that are homozygous for a disrupted TGF alpha gene allowed us to assess the requirement for this growth factor in these complex processes. We report here that although a 70% hepatectomy produced a...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 8597531
DOI: 10.1002/(sici)1098-2744(199603)15:3<183::aid-mc4>3.0.co;2-j

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