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Article

Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.

International journal of cancer - 15 Apr 2009

Marx-Stoelting Philip, Borowiak Malgorzata, Knorpp Thomas, Birchmeier Carmen, Buchmann Albrecht, Schwarz Michael

Abstract excerpt

The receptor for the hepatocyte growth factor/scatter factor (HGF/SF), c-Met, plays a role in tumour promotion, progression and metastasis. In this study, we analysed chemically induced hepatocarcinogenesis in mice lacking a functional HGF receptor in their liver. Control and c-Met deficient mice were injected with a single dose of N-nitrosodiethylamine (DEN, 90 mICROg/g b.wt.) at 6 weeks of age and mice were...

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Identifiers

PMID: 19123478
DOI: 10.1002/ijc.24167

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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