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Article

Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis.

Oncogene - 16 Aug 2001

Kanzler S, Meyer E, Lohse A W, Schirmacher P, Henninger J, Galle P R, Blessing M

Abstract excerpt

The potent growth-inhibitory activity of cytokines of the transforming growth factor-beta (TGF-beta) superfamily and their widespread expression in epithelia suggest that they may play an important role in the maintenance of epithelial homeostasis. To analyse TGF-beta mediated tumor suppressor activity in the liver, we generated transgenic mice overexpressing a dominant negative type II TGF-beta receptor in...

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C-Reactive Protein
Carcinoma, Hepatocellular
Hepatocytes
Liver Neoplasms, Experimental
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Transforming Growth Factor-beta Type II

Receptors, Transforming Growth Factor beta

Transforming Growth Factor beta

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PMID: 11526486
DOI: 10.1038/sj.onc.1204544

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