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Article

Minimal cooperation between mutant Hras and c-myc or TGFα in the regulation of mouse hepatocyte growth or transformation in vivo.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2011

Stein Timothy J, Bowden Margaret, Sandgren Eric P

Abstract excerpt

BACKGROUND: Liver carcinogenesis is associated with multiple genetic changes in affected cells, including alterations in the Hras signalling pathway. AIM: To define the biological contributions of Hras to mouse hepatocarcinogenesis, we quantified in vivo interactions between mutant Hras and other genetic alterations frequently associated with liver cancer, including overexpression of the transcription factor...

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Identifiers

PMID: 22093452
DOI: 10.1111/j.1478-3231.2011.02596.x
PMCID: PMC4317249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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