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Article

ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.

Cancer research - 15 Mar 2015

Song Xiaoling, Fan Pang-Dian, Bantikassegn Amlak, Guha Udayan, Threadgill David W, Varmus Harold, Politi Katerina

Abstract excerpt

ERBB3, a member of the EGFR family of receptor tyrosine kinases, has been implicated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR mutations. We investigated the contribution of ERBB3 to the initiation, progression, and therapeutic response of EGFR-induced lung adenocarcinomas using tetracycline- and tamoxifen-inducible transgenic mouse models. Deletion of Erbb3 at the time of...

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Identifiers

PMID: 25596284
DOI: 10.1158/0008-5472.CAN-13-1625
PMCID: PMC4400867

Genes

EGFR
ERBB3
ERBB2
GAB1
GAB2
MET

Variants

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