Article
The EGF receptor is required for efficient liver regeneration.
Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2007
Natarajan Anuradha, Wagner Bettina, Sibilia Maria
Abstract excerpt
Mice lacking the EGF receptor (EGFR) die between midgestation and postnatal day 20 with various defects in neural and epithelial organs. Here, we generated mice carrying a floxed EGFR allele to inactivate the EGFR in fetal and adult liver. Perinatal deletion of EGFR in hepatocytes resulted in decreased body weight, whereas deletion in the adult liver did not affect body mass. Although liver function was not...
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