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Article

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis

17 Jun 2008

Abstract excerpt

BACKGROUND: Overexpression of the human c-MYC (MYC) oncogene is one of the most frequently implicated events in the pathogenesis of hepatocellular carcinoma (HCC). Previously, we have shown in a conditional transgenic mouse model that MYC overexpression is restrained from inducing mitotic cellular division and tumorigenesis in the adult liver; whereas, in marked contrast, MYC induces robust proliferation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18560566
DOI: 10.1371/journal.pone.0002493

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