c-myc-induced hepatocarcinogenesis in the absence of IGF-I receptor.

doi:10.1002/ijc.20805

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Article

c-myc-induced hepatocarcinogenesis in the absence of IGF-I receptor.

International journal of cancer - 20 Apr 2005

Cadoret Axelle, Desbois-Mouthon Christèle, Wendum Dominique, Leneuve Patricia, Perret Christine, Tronche François, Housset Chantal, Holzenberger Martin

Abstract excerpt

Numerous tumours, including hepatocarcinomas, produce IGFs, and some depend on these growth factors in a paracrine or autocrine fashion. We have shown that c-myc-induced experimental hepatocarcinogenesis is associated with enhanced production of IGF-II. To assess the role of the IGF-I receptor (IGF-IR) in hepatocarcinogenesis, we generated conditional mutant mice that overexpressed c-myc and were knocked out for...

Topics

Alleles
Animals
Blotting, Western
Cell Proliferation
Genotype
Hepatocytes
Immunohistochemistry
Liver
Liver Neoplasms
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Promoter Regions, Genetic

Proto-Oncogene Proteins c-myc

Receptor, IGF Type 1

Recombination, Genetic

Reverse Transcriptase Polymerase Chain Reaction

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 15609331
DOI: 10.1002/ijc.20805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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