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Article

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53.

Cell - 24 Jan 2003

Eferl Robert, Ricci Romeo, Kenner Lukas, Zenz Rainer, David Jean-Pierre, Rath Martina, Wagner Erwin F

Abstract excerpt

The transcription factor c-Jun mediates several cellular processes, including proliferation and survival, and is upregulated in many carcinomas. Liver-specific inactivation of c-Jun at different stages of tumor development was used to study its role in chemically induced hepatocellular carcinomas (HCCs) in mice. The requirement for c-jun was restricted to early stages of tumor development, and the number and size...

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Source

Identifiers

PMID: 12553907
DOI: 10.1016/s0092-8674(03)00042-4

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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