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Article

Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression.

Nature communications - 22 Oct 2015

Kim Jong Kyoung, Kolodziejczyk Aleksandra A, Ilicic Tomislav, Illicic Tomislav, Teichmann Sarah A, Marioni John C

Abstract excerpt

Single-cell RNA-sequencing (scRNA-seq) facilitates identification of new cell types and gene regulatory networks as well as dissection of the kinetics of gene expression and patterns of allele-specific expression. However, to facilitate such analyses, separating biological variability from the high level of technical noise that affects scRNA-seq protocols is vital. Here we describe and validate a generative...

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Identifiers

PMID: 26489834
DOI: 10.1038/ncomms9687
PMCID: PMC4627577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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