Article

Coverage-dependent bias creates the appearance of binary splicing in single cells

2019-12-20

Abstract excerpt

Single cell RNA sequencing provides powerful insight into the factors that determine each cell’s unique identity, including variation in transcription and RNA splicing among diverse cell types. Previous studies led to the surprising observation that alternative splicing outcomes among single cells are highly variable and follow a bimodal pattern: a given cell consistently produces either one or the other isoform f...

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Literature Corpus work: 20f4e43c-eac7-5546-bb26-0037cc412649
DOI: 10.1101/2019.12.19.883256

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