Article
Distinct Transcript Isoforms of the Atypical Chemokine Receptor 1 (ACKR1)/Duffy Antigen Receptor for Chemokines (DARC) Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele.
PloS one - 1 Jan 2015
Davis Melissa B, Walens Andrea, Hire Rupali, Mumin Kauthar, Brown Andrea M, Ford DeJuana, Howerth Elizabeth W, Monteil Michele
Abstract excerpt
The Atypical ChemoKine Receptor 1 (ACKR1) gene, better known as Duffy Antigen Receptor for Chemokines (DARC or Duffy), is responsible for the Duffy Blood Group and plays a major role in regulating the circulating homeostatic levels of pro-inflammatory chemokines. Previous studies have shown that one common variant, the Duffy Null (Fy-) allele that is specific to African Ancestry groups, completely removes...
Topics
- Alleles
- Black People
- Cell Line
- Duffy Blood-Group System
- Gene Expression Regulation
- Humans
- Inflammation
- Lymphocytes
- Protein Isoforms
- Receptors, Cell Surface