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Article

Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease.

Journal of the American Society of Nephrology : JASN - 1 Apr 2026

Artinger Katharina, Novitzky-Basso Igor, Klötzer Konstantin A, Anto-Michel Nathaly, Schabhüttl Corinna, Gutjahr Julia Christine, Samus Maryna, Hub Elin, Kirsch Alexander H, Leitinger Daniel, Wernitznig Stefan, Umeizudike Theophilus, Pollheimer Marion, Ulvmar Maria H, Mooslechner Agnes A, Bacon Andrea, Eller Philipp, Kroneis Thomas, Kratky Dagmar, Rosenkranz Alexander R, Eller Kathrin, Rot Antal

Abstract excerpt

KEY POINTS: Selective erythroid atypical chemokine receptor 1 deficiency exacerbated disease activity in experimental GN via changes of the myeloid lineage. Activated monocytes and profibrogenic phenotypes of macrophages underlaid the kidney phenotype observed in erythroid-silent individuals. Genetically modified mouse models showed pathomechanisms of kidney diseases in patients of West African ancestry with...

Topics

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Duffy Blood-Group System
Fibrosis
Glomerulonephritis
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Receptors, Cell Surface

Receptors, Chemokine

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Identifiers

PMID: 40960880
DOI: 10.1681/ASN.0000000878
PMCID: PMC13065172

Genes

ACKR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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