Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

doi:10.1371/journal.pgen.1000360

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Article

Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

PLoS genetics - 1 Jan 2009

Reich David, Nalls Michael A, Kao W H Linda, Akylbekova Ermeg L, Tandon Arti, Patterson Nick, Mullikin James, Hsueh Wen-Chi, Cheng Ching-Yu, Coresh Josef, Boerwinkle Eric, Li Man, Waliszewska Alicja, Neubauer Julie, Li Rongling, Leak Tennille S, Ekunwe Lynette, Files Joe C, Hardy Cheryl L, Zmuda Joseph M, Taylor Herman A, Ziv Elad, Harris Tamara B, Wilson James G

Abstract excerpt

Persistently low white blood cell count (WBC) and neutrophil count is a well-described phenomenon in persons of African ancestry, whose etiology remains unknown. We recently used admixture mapping to identify an approximately 1-megabase region on chromosome 1, where ancestry status (African or European) almost entirely accounted for the difference in WBC between African Americans and European Americans. To...

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PMID: 19180233
DOI: 10.1371/journal.pgen.1000360
PMCID: PMC2628742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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